Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord.

Jinghong ChenQingjie LiGenevieve SaliukSonia BazhanovJohn H Winston

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)

Serotonin-mediated activation of 5HT3A receptors in the spinal cord drives the development of enhanced female-specific VHS in our two hit CPS+CAS through up-regulation of spinal cord ERα.

Keyphrases

spinal cord
stress induced
neuropathic pain
spinal cord injury
estrogen receptor
crispr cas
genome editing
type diabetes
breast cancer cells
drug induced
skeletal muscle