RIPK1 polymorphisms and expression levels: impact on genetic susceptibility and clinical outcome of epithelial ovarian cancer.

Xuedong WangKui DengJing TaoJuan ZouYiting DuLi Dai

Published in: Cancer cell international (2023)

Our results suggest that tag SNPs of RIPK1, increased plasma levels of RIPK1 protein and reduced RIPK1 mRNA expression in white blood cells, may influence the susceptibility to EOC. SNP rs6907943 may be a useful marker to distinguish EOC patients with high risk of death.

Keyphrases

genome wide
induced apoptosis
poor prognosis
cell cycle arrest
binding protein
dna methylation
copy number
cell death
gene expression
cell proliferation
small molecule
genetic diversity