Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition.

Allison M ClaasLyla AttaSimon GordonovAaron S MeyerDouglas A Lauffenburger

Published in: Cellular and molecular bioengineering (2018)

Our findings suggest that RTK reprogramming occurs through multiple mechanisms in a MAPK pathway target-specific manner, highlighting the need for comprehensive resistance mechanism profiling strategies during pharmacological development.

Keyphrases

tyrosine kinase
signaling pathway
epidermal growth factor receptor
oxidative stress
pi k akt
genome wide
single cell
gene expression
dna methylation