Douglas A Lauffenburger (Douglas Lauffenburger)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 65

Top Topics

Tyrosine Kinase

Immune Response

Dendritic Cells

Top Venues

Nature communications

NPJ systems biology and applications

Science translational medicine

Nature microbiology

This page only lists publications with an associated author ORCID identifier.

Publications

Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S Kane, Zoe Swank, Jameson P Davis, Melina Demokritou, Anagha P Chitnis, Alessio Fasano, Andrea G Edlow, Nitya Jain, Bruce H Horwitz, Ryan P McNamara, David R Walt, Douglas A Lauffenburger, Boris Julg, Wayne G Shreffler, Galit Alter, Lael M Yonker
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nature communications 15 (1) (2024)
Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S Kane, Zoe Swank, Jameson P Davis, Melina Demokritou, Anagha P Chitnis, Alessio Fasano, Andrea G Edlow, Nitya Jain, Bruce H Horwitz, Ryan P McNamara, David R Walt, Douglas A Lauffenburger, Boris Julg, Wayne G Shreffler, Galit Alter, Lael M Yonker
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nature communications 15 (1) (2024)
Shu Wang, Muhammad Ali Al-Radhawi, Douglas A Lauffenburger, Eduardo D Sontag
Recovering biomolecular network dynamics from single-cell omics data requires three time points. NPJ systems biology and applications 10 (1) (2024)
Leela R L Davies, Chuangqi Wang, Pia Steigler, Kathryn A Bowman, Stephanie Fischinger, Mark Hatherill, Michelle Fisher, Stanley Kimbung Mbandi, Miguel Rodo, Tom H M Ottenhoff, Hazel M Dockrell, Jayne S Sutherland, Harriet Mayanja-Kizza, W Henry Boom, Katharina Ronacher, Stefan H E Kaufmann, Elisa Nemes, Thomas Jens Scriba, Douglas A Lauffenburger, Galit Alter, Sarah M Fortune
Age and sex influence antibody profiles associated with tuberculosis progression. Nature microbiology (2024)
Marianna Spatola, Nadège Nziza, Edward B Irvine, Deniz Cizmeci, Wonyeong Jung, Le Hong Van, Le Thanh Hoang Nhat, Vu Thi Ngoc Ha, Nguyen Hoan Phu, Ho Dang Trung Nghia, Guy Thwaites, Douglas A Lauffenburger, Sarah Fortune, Nguyen Thuy Thuong Thuong, Galit Alter
Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection. Brain : a journal of neurology (2024)
Nikolaos Meimetis, Krista M Pullen, Daniel Y Zhu, Avlant Nilsson, Trong Nghia Hoang, Sara Magliacane, Douglas A Lauffenburger
AutoTransOP: translating omics signatures without orthologue requirements using deep learning. NPJ systems biology and applications 10 (1) (2024)
Leela R L Davies, Chuangqi Wang, Pia Steigler, Kathryn A Bowman, Stephanie Fischinger, Mark Hatherill, Michelle Fisher, Stanley Kimbung Mbandi, Miguel Rodo, Tom H M Ottenhoff, Hazel M Dockrell, Jayne S Sutherland, Harriet Mayanja-Kizza, W Henry Boom, Katharina Ronacher, Stefan H E Kaufmann, Elisa Nemes, Thomas Jens Scriba, Douglas A Lauffenburger, Galit Alter, Sarah M Fortune
Age and sex influence antibody profiles associated with tuberculosis progression. Nature microbiology 9 (6) (2024)
Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S Kane, Zoe Swank, Jameson P Davis, Melina Demokritou, Anagha P Chitnis, Alessio Fasano, Andrea G Edlow, Nitya Jain, Bruce H Horwitz, Ryan P McNamara, David R Walt, Douglas A Lauffenburger, Boris Julg, Wayne G Shreffler, Galit Alter, Lael M Yonker
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nature communications 15 (1) (2024)
Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey Jy Aw, Anisha Datta, Douglas A Lauffenburger, Andrea Pavesi, Michael E Birnbaum
Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma. bioRxiv : the preprint server for biology (2024)
Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S Kane, Zoe Swank, Jameson P Davis, Melina Demokritou, Anagha P Chitnis, Alessio Fasano, Andrea G Edlow, Nitya Jain, Bruce H Horwitz, Ryan P McNamara, David R Walt, Douglas A Lauffenburger, Boris Julg, Wayne G Shreffler, Galit Alter, Lael M Yonker
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nature communications 15 (1) (2024)
Leela R L Davies, Chuangqi Wang, Pia Steigler, Kathryn A Bowman, Stephanie Fischinger, Mark Hatherill, Michelle Fisher, Stanley Kimbung Mbandi, Miguel Rodo, Tom H M Ottenhoff, Hazel M Dockrell, Jayne S Sutherland, Harriet Mayanja-Kizza, W Henry Boom, Katharina Ronacher, Stefan H E Kaufmann, Elisa Nemes, Thomas Jens Scriba, Douglas A Lauffenburger, Galit Alter, Sarah M Fortune
Age and sex influence antibody profiles associated with tuberculosis progression. Nature microbiology 9 (6) (2024)
Caleb R Perez, Andrea Garmilla, Avlant Nilsson, Hratch M Baghdassarian, Khloe S Gordon, Louise G Lima, Blake E Smith, Marcela V Maus, Douglas A Lauffenburger, Michael E Birnbaum
Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence. bioRxiv : the preprint server for biology (2024)
Nikolaos Meimetis, Krista M Pullen, Daniel Y Zhu, Avlant Nilsson, Trong Nghia Hoang, Sara Magliacane, Douglas A Lauffenburger
AutoTransOP: translating omics signatures without orthologue requirements using deep learning. NPJ systems biology and applications 10 (1) (2024)
Ms Olyvia J Jasset, Paola Andrea Lopez Zapana, Zeynep Bahadir, Lydia L Shook, Ms Maria Dennis, Ms Emily Gilbert, Ms Zhaojing Ariel Liu, Ms Rachel V Yinger, Ms Caroline Bald, Ms Caroline G Bradford, Ms Alexa H Silfen, Sabra L Klein, Andrew S Pekosz, Sallie Permar, Liza Konnikova, Lael M Yonker, Douglas A Lauffenburger, Ashley Nelson, Michal A Elovitz, Andrea G Edlow
Longer interval between maternal RSV vaccination and birth increases placental transfer efficiency. medRxiv : the preprint server for health sciences (2024)
Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S Kane, Zoe Swank, Jameson P Davis, Melina Demokritou, Anagha P Chitnis, Alessio Fasano, Andrea G Edlow, Nitya Jain, Bruce H Horwitz, Ryan P McNamara, David R Walt, Douglas A Lauffenburger, Boris Julg, Wayne G Shreffler, Galit Alter, Lael M Yonker
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nature communications 15 (1) (2024)
Leela R L Davies, Chuangqi Wang, Pia Steigler, Kathryn A Bowman, Stephanie Fischinger, Mark Hatherill, Michelle Fisher, Stanley Kimbung Mbandi, Miguel Rodo, Tom H M Ottenhoff, Hazel M Dockrell, Jayne S Sutherland, Harriet Mayanja-Kizza, W Henry Boom, Katharina Ronacher, Stefan H E Kaufmann, Elisa Nemes, Thomas Jens Scriba, Douglas A Lauffenburger, Galit Alter, Sarah M Fortune
Age and sex influence antibody profiles associated with tuberculosis progression. Nature microbiology 9 (6) (2024)
Leela R L Davies, Chuangqi Wang, Pia Steigler, Kathryn A Bowman, Stephanie Fischinger, Mark Hatherill, Michelle Fisher, Stanley Kimbung Mbandi, Miguel Rodo, Tom H M Ottenhoff, Hazel M Dockrell, Jayne S Sutherland, Harriet Mayanja-Kizza, W Henry Boom, Katharina Ronacher, Stefan H E Kaufmann, Elisa Nemes, Thomas Jens Scriba, Douglas A Lauffenburger, Galit Alter, Sarah M Fortune
Age and sex influence antibody profiles associated with tuberculosis progression. Nature microbiology 9 (6) (2024)
Shu Wang, Muhammad Ali Al-Radhawi, Douglas A Lauffenburger, Eduardo D Sontag
Recovering biomolecular network dynamics from single-cell omics data requires three time points. NPJ systems biology and applications 10 (1) (2024)
Marianna Spatola, Nadège Nziza, Edward B Irvine, Deniz Cizmeci, Wonyeong Jung, Le Hong Van, Le Thanh Hoang Nhat, Vu Thi Ngoc Ha, Nguyen Hoan Phu, Dang Trung Nghia Ho, Guy E Thwaites, Douglas A Lauffenburger, Sarah Fortune, Nguyen Thuy Thuong Thuong, Galit Alter
Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection. Brain : a journal of neurology 147 (9) (2024)
Nikolaos Meimetis, Krista M Pullen, Daniel Y Zhu, Avlant Nilsson, Trong Nghia Hoang, Sara Magliacane, Douglas A Lauffenburger
AutoTransOP: translating omics signatures without orthologue requirements using deep learning. NPJ systems biology and applications 10 (1) (2024)
Shu Wang, Muhammad Ali Al-Radhawi, Douglas A Lauffenburger, Eduardo D Sontag
Recovering biomolecular network dynamics from single-cell omics data requires three time points. NPJ systems biology and applications 10 (1) (2024)
Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S Kane, Zoe Swank, Jameson P Davis, Melina Demokritou, Anagha P Chitnis, Alessio Fasano, Andrea G Edlow, Nitya Jain, Bruce H Horwitz, Ryan P McNamara, David R Walt, Douglas A Lauffenburger, Boris Julg, Wayne G Shreffler, Galit Alter, Lael M Yonker
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nature communications 15 (1) (2024)
Khloe S Gordon, Taeyoon Kyung, Caleb R Perez, Patrick V Holec, Azucena Ramos, Angela Q Zhang, Yash Agarwal, Yunpeng Liu, Catherine E Koch, Alina Starchenko, Brian A Joughin, Douglas A Lauffenburger, Darrell J Irvine, Michael T Hemann, Michael E Birnbaum
Author Correction: Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains. Nature biomedical engineering (2023)
Carolin Loos, Margherita Coccia, Arnaud M Didierlaurent, Ahmed Essaghir, Jonathan K Fallon, Douglas A Lauffenburger, Corinne Luedemann, Ashlin Michell, Robbert G van der Most, Alex Lee Zhu, Galit Alter, Wivine Burny
Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design. NPJ vaccines 8 (1) (2023)
Jonathan D Herman, Caroline Atyeo, Yonatan Zur, Claire E Cook, Naomi J Patel, Kathleen M M Vanni, Emily N Kowalski, Grace Qian, Shruthi Srivatsan, Nancy A Shadick, Deepak A Rao, Benjamin P Kellman, Colin J Mann, Douglas A Lauffenburger, Zachary Scott Wallace, Jeffrey A Sparks, Galit Alter
Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases. Science translational medicine 15 (712) (2023)
Marianna Spatola, Nadège Nziza, Wonyeong Jung, Yixiang Deng, Dansu Yuan, Alessandro Dinoto, Silvia Bozzetti, Vanessa Chiodega, Sergio Ferrari, Douglas A Lauffenburger, Sara Mariotto, Galit Alter
Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses. Brain : a journal of neurology (2023)
Vicky Roy, Wonyeong Jung, Caitlyn H Linde, Emily Coates, Julie Ledgerwood, Pamela Costner, Galina Yamshchikov, Hendrik Streeck, Boris Juelg, Douglas A Lauffenburger, Galit Alter
Differences in HPV-specific antibody Fc-effector functions following Gardasil® and Cervarix® vaccination. NPJ vaccines 8 (1) (2023)
Carolin Loos, Margherita Coccia, Arnaud M Didierlaurent, Ahmed Essaghir, Jonathan K Fallon, Douglas A Lauffenburger, Corinne Luedemann, Ashlin Michell, Robbert G van der Most, Alex Lee Zhu, Galit Alter, Wivine Burny
Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design. NPJ vaccines 8 (1) (2023)
Vicky Roy, Wonyeong Jung, Caitlyn H Linde, Emily Coates, Julie Ledgerwood, Pamela Costner, Galina Yamshchikov, Hendrik Streeck, Boris Juelg, Douglas A Lauffenburger, Galit Alter
Differences in HPV-specific antibody Fc-effector functions following Gardasil® and Cervarix® vaccination. NPJ vaccines 8 (1) (2023)
Avlant Nilsson, Joshua M Peters, Nikolaos Meimetis, Bryan D Bryson, Douglas A Lauffenburger
Artificial neural networks enable genome-scale simulations of intracellular signaling. Nature communications 13 (1) (2022)
Chuangqi Wang, Yijia Li, Paulina Kaplonek, Matteo Gentili, Stephanie Fischinger, Kathryn A Bowman, Moshe Sade-Feldman, Kyle R Kays, James Regan, James P Flynn, Marcia B Goldberg, Nir Hacohen, Michael R Filbin, Douglas A Lauffenburger, Galit Alter, Jonathan Z Li
The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia. mBio 13 (4) (2022)
Khloe S Gordon, Taeyoon Kyung, Caleb R Perez, Patrick V Holec, Azucena Ramos, Angela Q Zhang, Yash Agarwal, Yunpeng Liu, Catherine E Koch, Alina Starchenko, Brian A Joughin, Douglas A Lauffenburger, Darrell J Irvine, Michael T Hemann, Michael E Birnbaum
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains. Nature biomedical engineering 6 (7) (2022)
Felix Weiss, Douglas A Lauffenburger, Peter Friedl
Towards targeting of shared mechanisms of cancer metastasis and therapy resistance. Nature reviews. Cancer 22 (3) (2022)
Antonio G Dias, Caroline G Atyeo, Carolin Loos, Magelda Montoya, Vicky Roy, Sandra Bos, Parnal Narvekar, Tulika Singh, Leah C Katzelnick, Guillermina Kuan, Douglas A Lauffenburger, Angel Balmaseda, Galit Alter, Eva Harris
Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection. Science translational medicine 14 (651) (2022)
Paulina Kaplonek, Deniz Cizmeci, Stephanie Fischinger, Ai-Ris Y Collier, Todd J Suscovich, Caitlyn H Linde, Thomas Broge, Colin J Mann, Fatima Amanat, Diana Dayal, Justin Rhee, Michael de St Aubin, Eric James Nilles, Elon R Musk, Anil S Menon, Erica Ollmann Saphire, Florian Krammer, Douglas A Lauffenburger, Dan H Barouch, Galit Alter
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions. Science translational medicine 14 (645) (2022)
Martin Trapecar, Emile Wogram, Devon Svoboda, Catherine Communal, Attya Omer Javed, Tenzin Lungjangwa, Pierre Sphabmixay, Jason Velazquez, Kirsten Schneider, Charles W Wright, Samuel Mildrum, Austin Hendricks, Stuart S Levine, Julien Muffat, Meelim Jasmine Lee, Douglas A Lauffenburger, David Trumper, Rudolf Jaenisch, Linda G Griffith
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Science advances 7 (5) (2021)
Yannic C Bartsch, Stephanie Fischinger, Sameed M Siddiqui, Zhilin Chen, Jingyou Yu, Makda Gebre, Caroline G Atyeo, Matthew J Gorman, Alex Lee Zhu, Jaewon Kang, John S Burke, Matthew D Slein, Matthew J Gluck, Samuel Beger, Yiyuan Hu, Justin Rhee, Eric Petersen, Benjamin Mormann, Michael de St Aubin, Mohammad Adrian Hasdianda, Guruprasad Jambaulikar, Edward W Boyer, Pardis C Sabeti, Dan H Barouch, Boris D Julg, Elon R Musk, Anil S Menon, Douglas A Lauffenburger, Eric James Nilles, Galit Alter
Discrete SARS-CoV-2 antibody titers track with functional humoral stability. Nature communications 12 (1) (2021)
Caroline G Atyeo, Elizabeth A DeRiso, Christine Davis, Evan A Bordt, Rose M De Guzman, Lydia L Shook, Lael M Yonker, Alessio Fasano, Babatunde O Akinwunmi, Douglas A Lauffenburger, Michal A Elovitz, Kathryn J Gray Guseh, Andrea G Edlow, Galit Alter
COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women. Science translational medicine 13 (617) (2021)
Molly J Carroll, Natàlia Garcia-Reyero, Edward J Perkins, Douglas A Lauffenburger
Translatable pathways classification (TransPath-C) for inferring processes germane to human biology from animal studies data: example application in neurobiology. Integrative biology : quantitative biosciences from nano to macro (2021)
Todd J Suscovich, Jonathan K Fallon, Jishnu Das, Allison R Demas, Jonathan Crain, Caitlyn H Linde, Ashlin R Michell, Harini Natarajan, Claudia P Arevalo, Thomas Broge, Thomas Linnekin, Viraj Kulkarni, Richard Lu, Matthew D Slein, Corinne Luedemann, Meghan Marquette, Sandra March, Joshua A Weiner, Scott Gregory, Margherita Coccia, Yevel Flores-Garcia, Fidel Zavala, Margaret E Ackerman, Elke S Bergmann-Leitner, Jenny Hendriks, Jerald Sadoff, Sheetij Dutta, Sangeeta N Bhatia, Douglas A Lauffenburger, Erik Jongert, Ulrike Wille-Reece, Galit Alter
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination. Science translational medicine 12 (553) (2021)
Galit Alter, Matthew Gorman, Nita Patel, Mimi Guebre-Xabier, Alex Zhu, Caroline G Atyeo, Krista Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jing-Hui Tian, Dansu Yuan, Kathryn Bowman, Bin Zhou, Sonia Maciejewski, Marisa McGrath, James P Logue, Matthew B Friemann, David Montefiori, Sharon Schendel, Erica Ollmann Saphire, Douglas A Lauffenburger, Ann Greene, Alyse Portnoff, Michael Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Colin J Mann, Fatima Amanat, Florian Krammer
Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination. Research square (2021)
Paulina Kaplonek, Chuangqi Wang, Yannic C Bartsch, Stephanie Fischinger, Matthew J Gorman, Kathryn A Bowman, Jaewon Kang, Diana Dayal, Patrick Martin, Radosław P Nowak, Alexandra-Chloé Villani, Ching-Lin Hsieh, Nicole C Charland, Anna L K Gonye, Irena Gushterova, Hargun K Khanna, Thomas J LaSalle, Kendall M Lavin-Parsons, Brendan M Lilley, Carl L Lodenstein, Kasidet Manakongtreecheep, Justin D Margolin, Brenna N McKaig, Maricarmen Rojas-Lopez, Brian C Russo, Nihaarika Sharma, Jessica Tantivit, Molly Fisher Thomas, Moshe Sade-Feldman, Jared Feldman, Boris Julg, Eric J Nilles, Elon R Musk, Anil S Menon, Eric S Fischer, Jason S Mclellan, Aaron G Schmidt, Marcia B Goldberg, Michael R Filbin, Nir Hacohen, Douglas A Lauffenburger, Galit Alter
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19. Science immunology 6 (64) (2021)
Yannic C Bartsch, Chuangqi Wang, Tomer Zohar, Stephanie Fischinger, Caroline G Atyeo, John S Burke, Jaewon Kang, Andrea G Edlow, Alessio Fasano, Lindsey R Baden, Eric James Nilles, Ann E Woolley, Elizabeth W Karlson, Alex R Hopke, Daniel Irima, Eric S Fischer, Edward T Ryan, Richelle C Charles, Boris D Julg, Douglas A Lauffenburger, Lael M Yonker, Galit Alter
Humoral signatures of protective and pathological SARS-CoV-2 infection in children. Nature medicine 27 (3) (2021)
Jonathan D Herman, Chuangqi Wang, Carolin Loos, Hyunah Yoon, Johanna Rivera, Maria Eugenia Dieterle, Denise Haslwanter, Rohit K Jangra, Robert H Bortz, Katharine J Bar, Boris Julg, Kartik Chandran, Douglas A Lauffenburger, Liise-Anne Pirofski, Galit Alter
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response. Nature communications 12 (1) (2021)
Nader Morshed, Meelim J Lee, Felicia H Rodriguez, Douglas A Lauffenburger, Diego Mastroeni, Forest M White
Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease. Nature aging 1 (6) (2021)
Ran Li, Thomas S C Ng, Stephanie J Wang, Mark Prytyskach, Christopher Blake Rodell, Hannes Mikula, Rainer H Kohler, Michelle A Garlin, Douglas A Lauffenburger, Sareh Parangi, Daniela M Dinulescu, Nabeel Bardeesy, Ralph Weissleder, Miles A Miller
Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Nature nanotechnology 16 (7) (2021)
Nader Morshed, Meelim J Lee, Felicia H Rodriguez, Douglas A Lauffenburger, Diego Mastroeni, Forest M White
Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease. Nature aging 1 (6) (2021)
Evan A Bordt, Lydia L Shook, Caroline G Atyeo, Krista M Pullen, Rose M De Guzman, Marie-Charlotte Meinsohn, Maeva Chauvin, Stephanie Fischinger, Laura J Yockey, Kaitlyn James, Rosiane Lima, Lael M Yonker, Alessio Fasano, Sara Brigida, Lisa M Bebell, Drucilla J Roberts, David Pépin, Jun R Huh, Staci D Bilbo, Jonathan Z Li, Anjali Kaimal, Danny J Schust, Kathryn J Gray Guseh, Douglas A Lauffenburger, Galit Alter, Andrea G Edlow
Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. Science translational medicine 13 (617) (2021)
Gaurav Luthria, Ran Li, Stephanie Wang, Mark Prytyskach, Rainer H Kohler, Douglas A Lauffenburger, Timothy J Mitchison, Ralph Weissleder, Miles A Miller
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nature communications 11 (1) (2020)
Douglas K Brubaker, Manu P Kumar, Evan L Chiswick, Cecil Gregg, Alina Starchenko, Paige N Vega, Austin N Southard-Smith, Alan J Simmons, Elizabeth A Scoville, Lori A Coburn, Keith T Wilson, Ken S Lau, Douglas A Lauffenburger
An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease. Science signaling 13 (643) (2020)
Katherine McMahan, Jingyou Yu, Noe B Mercado, Carolin Loos, Lisa H Tostanoski, Abishek Chandrashekar, Jinyan Liu, Lauren Peter, Caroline Atyeo, Alex Lee Zhu, Esther A Bondzie, Gabriel Dagotto, Makda S Gebre, Catherine Jacob-Dolan, Zhenfeng Li, Felix Nampanya, Shivani Patel, Laurent Pessaint, Alex Van Ry, Kelvin Blade, Jake Yalley-Ogunro, Mehtap Cabus, Renita Brown, Anthony Cook, Elyse Teow, Hanne A Elyard, Mark G Lewis, Douglas A Lauffenburger, Galit Alter, Dan H Barouch
Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature 590 (7847) (2020)
Stephanie J Wang, Ran Li, Thomas S C Ng, Gaurav Luthria, Madeleine J Oudin, Mark Prytyskach, Rainer H Kohler, Ralph Weissleder, Douglas A Lauffenburger, Miles A Miller
Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Science advances 6 (21) (2020)
Lauren E Stopfer, Joshua M Mesfin, Brian A Joughin, Douglas A Lauffenburger, Forest M White
Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition. Nature communications 11 (1) (2020)
Noe B Mercado, Roland Zahn, Frank Wegmann, Carolin Loos, Abishek Chandrashekar, Jingyou Yu, Jinyan Liu, Lauren Peter, Katherine McMahan, Lisa H Tostanoski, Xuan He, David R Martinez, Lucy Rutten, Rinke Bos, Danielle van Manen, Jort Vellinga, Jerome Custers, Johannes P Langedijk, Ted Kwaks, Mark J G Bakkers, David Zuijdgeest, Sietske K Rosendahl Huber, Caroline Atyeo, Stephanie Fischinger, John S Burke, Jared Feldman, Blake M Hauser, Timothy M Caradonna, Esther A Bondzie, Gabriel Dagotto, Makda S Gebre, Emily Hoffman, Catherine Jacob-Dolan, Marinela Kirilova, Zhenfeng Li, Zijin Lin, Shant H Mahrokhian, Lori F Maxfield, Felix Nampanya, Ramya Nityanandam, Joseph P Nkolola, Shivani Patel, John D Ventura, Kaylee Verrington, Huahua Wan, Laurent Pessaint, Alex Van Ry, Kelvin Blade, Amanda Strasbaugh, Mehtap Cabus, Renita Brown, Anthony Cook, Serge Zouantchangadou, Elyse Teow, Hanne A Elyard, Mark G Lewis, Yongfei Cai, Bing Chen, Aaron G Schmidt, R Keith Reeves, Ralph S Baric, Douglas A Lauffenburger, Galit Alter, Paul Stoffels, Mathai Mammen, Johan Van Hoof, Hanneke Schuitemaker, Dan H Barouch
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586 (7830) (2020)
Jishnu Das, Anush Devadhasan, Caitlyn H Linde, Tom Broge, Jessica Sassic, Max Mangano, Sean O'Keefe, Todd J Suscovich, Hendrik Streeck, Alivelu Irrinki, Christopher W Pohlmeyer, Gundula Min-Oo, Shu Lin, Joshua A Weiner, Thomas Cihlar, Margaret E Ackerman, Boris Julg, Steven G Deeks, Douglas A Lauffenburger, Galit Alter
Mining for humoral correlates of HIV control and latent reservoir size. PLoS pathogens 16 (10) (2020)
Lisa H Tostanoski, Frank Wegmann, Amanda J Martinot, Carolin Loos, Katherine McMahan, Noe B Mercado, Jingyou Yu, Chi Ngai Chan, Stephen Bondoc, Carly E Starke, Michael Nekorchuk, Kathleen Busman-Sahay, Cesar Piedra-Mora, Linda M Wrijil, Sarah Ducat, Jerome Custers, Caroline Atyeo, Stephanie Fischinger, John S Burke, Jared Feldman, Blake M Hauser, Timothy M Caradonna, Esther A Bondzie, Gabriel Dagotto, Makda S Gebre, Catherine Jacob-Dolan, Zijin Lin, Shant H Mahrokhian, Felix Nampanya, Ramya Nityanandam, Laurent Pessaint, Maciel Porto, Vaneesha Ali, Dalia Benetiene, Komlan Tevi, Hanne A Elyard, Mark G Lewis, Aaron G Schmidt, Douglas A Lauffenburger, Galit Alter, Jacob D Estes, Hanneke Schuitemaker, Roland C Zahn, Dan H Barouch
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nature medicine 26 (11) (2020)
Elizabeth A Proctor, Shauna M Dineen, Stephen C Van Nostrand, Madison K Kuhn, Christopher D Barrett, Douglas K Brubaker, Michael B Yaffe, Douglas A Lauffenburger, Lisa R Leon
Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model. Journal of thrombosis and haemostasis : JTH 18 (8) (2020)
Giuseppe Lofano, Matthew J Gorman, Ashraf S Yousif, Wen Han Yu, Julie M Fox, Anne-Sophie Dugast, Margaret E Ackerman, Todd J Suscovich, Joshua A Weiner, Dan H Barouch, Hendrik Streeck, Susan J Little, Davey Smith, Douglas D Richman, Douglas A Lauffenburger, Bruce D Walker, Michael S. Diamond, Galit Alter
Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. Science immunology 3 (26) (2019)
Melissa A Kinney, Linda T Vo, Jenna M Frame, Jessica Barragan, Ashlee J Conway, Shuai Li, Kwok-Kin Wong, James J Collins, Patrick Cahan, Trista E North, Douglas A Lauffenburger, George Q Daley
A systems biology pipeline identifies regulatory networks for stem cell engineering. Nature biotechnology 37 (7) (2019)
Douglas K Brubaker, Elizabeth A Proctor, Kevin M Haigis, Douglas A Lauffenburger
Computational translation of genomic responses from experimental model systems to humans. PLoS computational biology 15 (1) (2019)
Jesse Lyons, Douglas K Brubaker, Phaedra C Ghazi, Katherine R Baldwin, Amanda Edwards, Myriam Boukhali, Samantha Dale Strasser, Lucia Suarez-Lopez, Yi-Jang Lin, Vijay Yajnik, Joseph L Kissil, Wilhelm Haas, Douglas A Lauffenburger, Kevin M Haigis
Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Science signaling 11 (519) (2018)
Wen-Han Yu, Peng Zhao, Monia Draghi, Claudia Arevalo, Christina B Karsten, Todd J Suscovich, Bronwyn Gunn, Hendrik Streeck, Abraham L Brass, Michael Tiemeyer, Michael Seaman, John R Mascola, Lance Wells, Douglas A Lauffenburger, Galit Alter
Exploiting glycan topography for computational design of Env glycoprotein antigenicity. PLoS computational biology 14 (4) (2018)
Allison M Claas, Lyla Atta, Simon Gordonov, Aaron S Meyer, Douglas A Lauffenburger
Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition. Cellular and molecular bioengineering 11 (6) (2018)
Douglas S Jones, Anne P Jenney, Brian A Joughin, Peter Karl Sorger, Douglas A Lauffenburger
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Science signaling 11 (520) (2018)
Wen L K Chen, Collin Edington, Emily Suter, Jiajie Yu, Jeremy J Velazquez, Jason G Velazquez, Michael Shockley, Emma M Large, Raman Venkataramanan, David J Hughes, Cynthia L Stokes, David L Trumper, Rebecca L Carrier, Murat Cirit, Linda G Griffith, Douglas A Lauffenburger
Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk. Biotechnology and bioengineering 114 (11) (2017)