Clinical value of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis.
Sei-Ichiro MotegiChisako FujiwaraAkiko SekiguchiKenichiro HaraKoichi YamaguchiToshitaka MaenoTetsuya HiguchiHiromi HirasawaSayaka KodairaHiroyasu TomonagaYoshito TsushimaOsamu IshikawaPublished in: The Journal of dermatology (2019)
18 F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is usually used to screen malignancy in patients with dermatomyositis (DM). Additionally, it is well known that FDG-PET/CT provides valuable information for evaluating the activity of several inflammatory diseases, such as sarcoidosis, atherosclerosis, inflammatory bowel disease and rheumatoid arthritis. Therefore, the objective of this study was to evaluate the clinical usefulness of FDG-PET/CT for the detection of inflammatory lesions and disease activity of both myopathy and interstitial lung disease (ILD) in DM patients. We measured the maximum standardized uptake value (SUVmax) in the muscles and lungs in 22 DM patients, and compared with magnetic resonance imaging (MRI) and high-resolution computed tomography (HRCT) findings in the same muscle and lung regions as well as with clinical findings. We found that the location of increased FDG uptake was nearly consistent with the region of ILD and myositis detected by HRCT or MRI, respectively. There was a significant positive correlation between lung HRCT score and SUVmax in each lung. Serum Krebs von den Lungen-6 levels also revealed significant positive correlation with total SUVmax of right and left lungs. Regarding FDG-PET/CT and myopathy, total SUVmax in the muscles was significantly correlated with serum cytokeratin levels. Our results suggest that FDG uptake (SUVmax) might be useful for not only the detection of malignant tumors, but also the evaluation of the location and activity of ILD and myositis in DM patients.
Keyphrases
- positron emission tomography
- interstitial lung disease
- computed tomography
- rheumatoid arthritis
- systemic sclerosis
- magnetic resonance imaging
- disease activity
- idiopathic pulmonary fibrosis
- contrast enhanced
- end stage renal disease
- pet imaging
- pet ct
- ejection fraction
- newly diagnosed
- high resolution
- chronic kidney disease
- dual energy
- prognostic factors
- metabolic syndrome
- healthcare
- ankylosing spondylitis
- type diabetes
- systemic lupus erythematosus
- cardiovascular disease
- peritoneal dialysis
- social media
- high throughput
- skeletal muscle
- image quality
- early onset
- late onset
- weight loss
- juvenile idiopathic arthritis
- rheumatoid arthritis patients