Effects of PI3K inhibition in AI-resistant breast cancer cell lines: autophagy, apoptosis, and cell cycle progression.

Tiago V AugustoCristina AmaralYuanzhong WangShiuan ChenCristina F AlmeidaNatércia TeixeiraGeorgina Correia-da-Silva

Published in: Breast cancer research and treatment (2021)

These results corroborate the lack of cross-resistance between AIs verified in the clinic, excluding autophagy as a mechanism of resistance to Ana or Let and supporting the ongoing clinical trials combining BYL-719 with AIs.

Keyphrases

cell cycle
endoplasmic reticulum stress
cell death
oxidative stress
clinical trial
cell proliferation
signaling pathway
cell cycle arrest
primary care
artificial intelligence
randomized controlled trial
study protocol
deep learning