Targeting FGFR3 is a Useful Therapeutic Strategy for Rheumatoid Arthritis Treatment.
Shan-Fu YuTien-Tsai ChengGong-Kai HuangChung-Yuan HsuYing-Hsien KaoYueh-Hua ChungPublished in: Current molecular pharmacology (2023)
Genetic interference of FGFR3 could modulate the expression of inflammatory mediators and EMT markers in the synovial cells. Targeting the FGFR3/MAPK signal axis may be considered a useful therapeutic strategy to ameliorate the development of RA.
Keyphrases
- rheumatoid arthritis
- induced apoptosis
- oxidative stress
- disease activity
- cancer therapy
- poor prognosis
- signaling pathway
- cell cycle arrest
- epithelial mesenchymal transition
- ankylosing spondylitis
- interstitial lung disease
- pi k akt
- genome wide
- copy number
- cell proliferation
- systemic sclerosis
- long non coding rna
- idiopathic pulmonary fibrosis
- replacement therapy
- smoking cessation