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Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations.

Alexander PopDina Halegoua-DeMarzioHuiman BarnhartDavid KleinerMark AviganJiezhun GuNaga ChalasaniJawad AhmadRobert J FontanaWilliam LeeA Sidney BarrittFrancisco DurazoPaul H HayashiVictor J Navarro
Published in: Digestive diseases and sciences (2024)
Amiodarone hepatotoxicity resembles that seen in alcohol related liver injury, with fatty infiltration and inflammation. Dronedarone is less predictable, typically without fat and with a shorter latency of use before presentation. These differences may be explained, in part, by the differing pharmacokinetics of the two drugs leading to different mechanisms of hepatotoxicity.
Keyphrases
  • drug induced
  • liver injury
  • oxidative stress
  • fatty acid
  • adipose tissue
  • case report
  • alcohol consumption