Overexpression of SIRT6 alleviates apoptosis and enhances cell viability and monoclonal antibody expression in CHO-K1 cells.

Nader HashemiSayed Hassan TabatabaeeForough ShamsAzam RahimpourBahram KazemiMasoumeh RajabibazlJavad Ranjbari

Published in: Molecular biology reports (2023)

This study indicates the positive effects of SIRT6 overexpression on cell viability and anti-CD52 IgG1 mAb expression in CHO-K1 cells. Further studies are needed to examine the potential of SIRT6-engineered host cells for the production of recombinant biotherapeutics in industrial settings.

Keyphrases

cell cycle arrest
induced apoptosis
oxidative stress
monoclonal antibody
poor prognosis
cell death
cell proliferation
pi k akt
heavy metals
case control
climate change