Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease.

Simeng Lin Eilis J HannonMark ReppellJeffrey F WaringNizar SmaouiValerie PivorunasHeath GuayNeil Chanchlani Claire M Bewshea Benjamin Y H BaiNicholas A KennedyJames R GoodhandJonathan MillTariq Ahmadnull null

Published in: Journal of Crohn's & colitis (2023)

Baseline DNA methylation profiles may be used as a predictor for anti-TNF drug concentration at week 14 to identify patients who may benefit from dose optimisation at the outset of anti-TNF therapy.

Keyphrases

dna methylation
rheumatoid arthritis
genome wide
gene expression
clinical trial
randomized controlled trial
drug induced
adverse drug
copy number
cell therapy
smoking cessation
double blind
placebo controlled