Palladium-NHC-Catalyzed Allylic Alkylation of Pronucleophiles with Alkynes.

Wei RenQian-Ming ZuoYan-Ning NiuShang-Dong Yang

Published in: Organic letters (2019)

The palladium-N-heterocyclic carbene (NHC)-catalyzed allylic alkylation of various pronucleophiles with alkynes has been accomplished under mild conditions. The protocol exhibits broad functional group compatibility and high atom economy. Moreover, the catalytic process avoids the use of external oxidants and acid as additives.

Keyphrases

room temperature
reduced graphene oxide
ionic liquid
randomized controlled trial
molecular dynamics
crystal structure