Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity.

João Manuel SantosCamilla HeiniöVictor Cervera-CarrasconDafne C A QuixabeiraMikko SiuralaRiikka HavunenRalf ButzowSadia ZafarTanja de GruijlHeini LassusAnna KanervaAkseli E Hemminki

Published in: Journal for immunotherapy of cancer (2020)

Overall, oncolytic adenovirus Ad5/3-E2F-D24-hTNFa-IRES-hIL2 was able to rewire the ovarian tumor microenvironment to accommodate heightened antitumor TIL reactivity. Such effects may improve the clinical effectiveness of ACT with TILs in patients with advanced OVCA.

Keyphrases

randomized controlled trial
gene therapy
systematic review
peripheral blood