Caspase-1 Enhances TANGO1 Expression to Promote Procollagen Export from the Endoplasmic Reticulum in Systemic Sclerosis Contributing to Fibrosis.

TANGO1 is markedly increased in SSc fibroblasts and found elevated in lung tissue in association with α-SMA positive cells. TANGO1 expression is driven by inflammasome-dependent caspase-1 activation and is mediated by IL-1 and TGF-β downstream signaling. These observations suggest that during fibrosis, caspase-1 promotes the upregulation of TANGO1, and the organization of ER exits sites, ultimately contributing to procollagen export and fibrosis. This article is protected by copyright. All rights reserved.