Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I.
Qi ZhangGang ChengJing PanJacek ZielonkaDonghai XiongCharles R MyersLiang FengSong Seok ShinYoung Heui KimDinh BuiMing HuBrian BennettKathleen SchmaindaYian WangBalaraman KalyanaramanMing YouPublished in: Cell communication and signaling : CCS (2020)
Our data using highly relevant preclinical oral cancer models, which share histopathological features seen in human oral carcinogenesis, suggest a novel signaling and regulatory role for mitochondria-generated superoxide and hydrogen peroxide in suppressing oral cancer cell proliferation, progression, and metastasis. Video abstract.
Keyphrases
- hydrogen peroxide
- cell proliferation
- nitric oxide
- oxidative stress
- endothelial cells
- transcription factor
- cell death
- electronic health record
- signaling pathway
- cell cycle
- induced pluripotent stem cells
- cell therapy
- big data
- machine learning
- pluripotent stem cells
- mesenchymal stem cells
- endoplasmic reticulum
- data analysis