MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
Asma A BatarfiNajlaa FilimbanOsama S BajouhAshraf DallolAdeel G ChaudharyJolanta U WeaverPublished in: BMC medical genetics (2019)
These findings demonstrate that MC4R single nucleotide polymorphisms, rs12970134 and rs17782313, are correlated with elevated BMI in PCOS but are not causative factors for PCOS among women in the western region of Saudi Arabia. Moreover, the reverse genotypes are associated with major clinical variants in non-obese (< 30 kg/m2) PCOS patients may demonstrate a poor prognosis for this group.
Keyphrases
- polycystic ovary syndrome
- saudi arabia
- poor prognosis
- end stage renal disease
- insulin resistance
- ejection fraction
- adipose tissue
- newly diagnosed
- chronic kidney disease
- long non coding rna
- metabolic syndrome
- peritoneal dialysis
- type diabetes
- prognostic factors
- south africa
- copy number
- body mass index
- bariatric surgery
- patient reported outcomes
- skeletal muscle
- gene expression
- physical activity
- genome wide
- patient reported