Inferred immune-cell activity is an independent predictor of HER2 negative breast cancer prognosis and response to paclitaxel-based therapy in the GeparSepto trial.

Peter Andreas Fasching Christopher W Szeto Carsten Denkert Stephen Charles Benz Karsten E Weber Patricia Spilman Jan Budczies Andreas Schneeweiß Elmar Stickeler Sabine Schmatloch Christian Jackisch Thomas Karn Hans-Peter Sinn Mathias Warm Marion T van Mackelenbergh Shahrooz Rabizadeh Christian Schem Ernst Heinmöller Volkmar Mueller Frederic Marmé Patrick Soon-Shiong Valentina Nekljudova Michael Untch Sibylle Loibl

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Overall, TIL level better predicted pCR, but iICA cluster better predicted survival. Differences in associations between TILs, cluster, pCR and survival were observed for HR positive versus negative tumors, suggesting expanded study of the implication of these findings is warranted.

Keyphrases

free survival
clinical trial
study protocol
stem cells
randomized controlled trial
replacement therapy