Systems analysis of benign bladder disorders: insights from omics analysis.
Ali Hashemi GheinaniAlexander Bigger-AllenAmanda WackerRosalyn M AdamPublished in: American journal of physiology. Renal physiology (2020)
The signaling pathways and effectors that drive the response of the bladder to nonmalignant insults or injury are incompletely defined. Interrogation of biological systems has been revolutionized by the ability to generate high-content data sets that capture information on a variety of biomolecules in cells and tissues, from DNA to RNA to proteins. In oncology, such an approach has led to the identification of cancer subtypes, improved prognostic capability, and has provided a basis for precision treatment of patients. In contrast, systematic molecular characterization of benign bladder disorders has lagged behind, such that our ability to uncover novel therapeutic interventions or increase our mechanistic understanding of such conditions is limited. Here, we discuss existing literature on the application of omics approaches, including transcriptomics and proteomics, to urinary tract conditions characterized by pathological tissue remodeling. We discuss molecular pathways implicated in remodeling, challenges in the field, and aspirations for omics-based research in the future.
Keyphrases
- urinary tract
- single cell
- induced apoptosis
- spinal cord injury
- signaling pathway
- systematic review
- papillary thyroid
- single molecule
- cell cycle arrest
- gene expression
- mass spectrometry
- magnetic resonance
- palliative care
- circulating tumor
- nucleic acid
- squamous cell carcinoma
- cell free
- big data
- magnetic resonance imaging
- electronic health record
- current status
- health information
- squamous cell
- epithelial mesenchymal transition
- oxidative stress
- machine learning
- computed tomography
- lymph node metastasis
- bioinformatics analysis
- cell death
- circulating tumor cells
- childhood cancer