Sirtuins and Cellular Senescence in Patients with Idiopathic Pulmonary Fibrosis and Systemic Autoimmune Disorders.
Vito D'AgnanoDomenica Francesca MarinielloRaffaella PagliaroMehrdad Savabi FarAngela SchiattarellaFilippo ScialòGiulia StellaMaria Gabriella MateraMario CazzolaAndrea BiancoFabio PerrottaPublished in: Drugs (2024)
The sirtuin family is a heterogeneous group of proteins that play a critical role in many cellular activities. Several degenerative diseases have recently been linked to aberrant sirtuin expression and activity because of the involvement of sirtuins in maintaining cell longevity and their putative antiaging function. Idiopathic pulmonary fibrosis and progressive pulmonary fibrosis associated with systemic autoimmune disorders are severe diseases characterized by premature and accelerated exhaustion and failure of alveolar type II cells combined with aberrant activation of fibroblast proliferative pathways leading to dramatic destruction of lung architecture. The mechanisms underlying alveolar type II cell exhaustion in these disorders are not fully understood. In this review, we have focused on the role of sirtuins in the pathogenesis of idiopathic and secondary pulmonary fibrosis and their potential as biomarkers in the diagnosis and management of fibrotic interstitial lung diseases.
Keyphrases
- idiopathic pulmonary fibrosis
- pulmonary fibrosis
- multiple sclerosis
- interstitial lung disease
- single cell
- cell therapy
- drug induced
- induced apoptosis
- poor prognosis
- dna damage
- early onset
- stem cells
- endoplasmic reticulum stress
- rheumatoid arthritis
- mesenchymal stem cells
- bone marrow
- cell proliferation
- binding protein
- stress induced
- wound healing