Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.
Victor A Del BeneRoy C MartinSarah A BrinkerhoffJoseph W OlsonMatthew J NelsonDario MarottaChristopher L GonzalezKelly A MillsVidyulata KamathGary CutterChris P HurtMelissa WadeFrank G RobinsonJ Nicole BentleyBarton L GuthrieRobert T KnightHarrison C WalkerPublished in: Annals of neurology (2024)
Directional versus ring STN DBS did not differentially affect cognition. Similar to prior bilateral DBS studies, unilateral left stimulation worsened verbal fluency performance. In contrast, unilateral right STN surgery increased performance on verbal fluency and response inhibition tasks. Our findings raise the hypothesis that unilateral right STN DBS in selected patients with predominant right brain motor parkinsonism could mitigate declines in verbal fluency associated with the bilateral intervention. ANN NEUROL 2024;95:1205-1219.
Keyphrases
- deep brain stimulation
- parkinson disease
- working memory
- obsessive compulsive disorder
- randomized controlled trial
- white matter
- magnetic resonance
- case report
- coronary artery bypass
- mild cognitive impairment
- coronary artery disease
- resting state
- magnetic resonance imaging
- functional connectivity
- acute coronary syndrome
- contrast enhanced
- neural network
- brain injury