Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype.
Marpe BamXiaoming YangBrandon P BusbeeAllison E AielloMonica UddinJay P GinsbergSandro GaleaPrakash S NagarkattiMitzi NagarkattiPublished in: Molecular medicine (Cambridge, Mass.) (2020)
In summary, our data demonstrate for the first time that Wnt signaling pathway is upregulated in PBMCs of PTSD patients resulting from epigenetic changes involving microRNA dysregulation and histone modifications, which in turn may promote the inflammatory phenotype in such cells.
Keyphrases
- end stage renal disease
- signaling pathway
- ejection fraction
- newly diagnosed
- dna methylation
- stem cells
- induced apoptosis
- cell proliferation
- peritoneal dialysis
- oxidative stress
- poor prognosis
- machine learning
- patient reported outcomes
- epithelial mesenchymal transition
- cell death
- pi k akt
- artificial intelligence
- genome wide
- quantum dots
- single molecule
- living cells