[Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome].

Andranik Alexandrovich Muradian Dmitry Alekseevich Sychev Dmitry Alekseevich Blagovestnov D I Petrov D S Skukin I P Epifanova Zhannet Alimovna Sozaeva Anastasiya A Kachanova Natalia P Denisenko Sherzod Pardaboevich Abdullaev Elena A Grishina

Published in: Terapevticheskii arkhiv (2022)

In carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080), the effectiveness of anesthesia with ketorolac is higher than in carriers of the wild type. Carriage of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs10509681) does not affect the risk of developing adverse reactions after ketorolac anesthesia.

Keyphrases

wild type
randomized controlled trial
emergency department
gene expression
genome wide
copy number
drug induced
genome wide identification