Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination.

Anjali YadavTzu-Chieh HuangSzu-Han ChenThamil Selvee RamasamyYuan-Yu HsuehShau-Ping LinFu-I LuYa-Hsin LiuChia-Ching Wu

Published in: Journal of neuroinflammation (2021)

Suppressing the lengthened state of inflammation using PBA treatment favors axonal regrowth and remyelination following nerve transection injury. PBA treatment also regulates pro-inflammatory cytokine expression by inhibiting the transcriptional activation of NFκB-p65 and HDAC3 in SCs in vitro.

Keyphrases

signaling pathway
oxidative stress
spinal cord injury
stem cells
poor prognosis
gene expression
single cell
pi k akt
transcription factor
nuclear factor
peripheral nerve
inflammatory response
long non coding rna
toll like receptor
heat shock
optical coherence tomography