Beneficial effects of maternal swimming during pregnancy on offspring metabolism when the father is obese.
R TarevnicF OrnellasCarlos Alberto Mandarim-de-LacerdaM B AguilaPublished in: Journal of developmental origins of health and disease (2018)
We aimed to evaluate the impact of maternal exercise training on the offspring metabolism and body size caused by father obesity. C57BL/6 male 4-week-old mice were fed a high-fat diet (HF father) or control diet (C father), while equal age female mice were fed only a C diet and were separated into two groups: trained (T mother) and non-trained (NT mother), and at 12 weeks of age mice were mated. A continuous swimming protocol was applied for 10 weeks (before and during gestation), and offspring were followed since weaning until sacrifice (at 12 weeks of age). HF father, compared to C father, showed obesity, elevated total cholesterol (TC) and triglycerides (TG), and glucose intolerance. Both sexes HF/NT offspring showed hyperglycemia, glucose intolerance and high levels of TC and TG, without obesity. However, HF/T offspring showed data close to C/NT, demonstrating the beneficial effect of maternal exercise in the offspring of obese fathers.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- adipose tissue
- weight loss
- metabolic syndrome
- type diabetes
- skeletal muscle
- gestational age
- birth weight
- bariatric surgery
- physical activity
- resistance training
- acute heart failure
- randomized controlled trial
- preterm infants
- pregnancy outcomes
- heart failure
- atrial fibrillation
- clinical trial
- body mass index
- preterm birth
- high intensity
- electronic health record
- machine learning
- blood glucose
- data analysis
- extracorporeal membrane oxygenation
- deep learning
- artificial intelligence
- double blind