Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.

Matt L HarlowMaggie H ChasseElissa A BoguslawskiKatie M SorensenJenna M GedminasSusan M Kitchen-GoosenScott B Rothbart Cenny TaslimStephen L LessnickAnderson S PeckZachary B MadajMegan J BowmanPatrick J Grohar

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These data provide the justification to evaluate trabectedin in the clinic on a short infusion schedule in combination with low-dose irinotecan with 18F-FLT PET imaging in patients with Ewing sarcoma.

Keyphrases

pet imaging
low dose
acute myeloid leukemia
high dose
positron emission tomography
electronic health record
gene expression
primary care
dna damage
tyrosine kinase
transcription factor
genome wide
big data
computed tomography
dna methylation
artificial intelligence