Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence.
Samir TivariHaiyan LuTanya DasguptaMariana S De LorenzoRobert WiederPublished in: Cell communication and signaling : CCS (2018)
Dormant ER+ breast cancer cells have activated epithelial mesenchymal transition (EMT) gene expression programs and downregulated ERα but maintain a dormant epithelial phenotype. Stromal inflammation reactivates these cells, induces growth and a mesenchymal phenotype. Reactivated, growing cells have an impaired ability to re-enter dormancy. In turn, breast cancer cells co-cultured with stroma induce secretion of IL-6 and IL-8 by the stroma, creating a positive feedback loop.
Keyphrases
- breast cancer cells
- bone marrow
- epithelial mesenchymal transition
- induced apoptosis
- gene expression
- endothelial cells
- cell cycle arrest
- oxidative stress
- mesenchymal stem cells
- dna methylation
- signaling pathway
- estrogen receptor
- stem cells
- public health
- transforming growth factor
- cell death
- single molecule
- living cells
- transcription factor
- stress induced
- pluripotent stem cells