Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery.
Paulo Emílio Corrêa LeiteMariana Rodrigues PereiraGeorgina HarrisDavid PamiesLisia Maria Gobbo Dos SantosJosé Mauro GranjeiroHelena T HogbergThomas HartungLena SmirnovaPublished in: Particle and fibre toxicology (2019)
3D brain models, both monocellular and multicellular are useful in studying NP neurotoxicity and can help identify how specific cell types of CNS are affected by NP.