The impact of demographic, clinical, genetic, and imaging variables on tau PET status.

Rik OssenkoppeleAntoine LeuzyHanna ChoCarole H SudreOlof StrandbergRuben SmithSebastian PalmqvistNiklas Mattsson-CarlgrenTomas OlssonJonas JögiErik StormrudYoung Hoon RyuJae Yong Choinull nullnull nullAdam L BoxerMaria L Gorno-TempiniBruce L MillerDavid Soleimani-MeigooniLeonardo IaccarinoRenaud La JoieEdilio BorroniGregory KleinMichael J PontecorvoMichael D DevousSylvia VilleneuveChul Hyoung LyooGil D RabinoviciOskar Hansson

Published in: European journal of nuclear medicine and molecular imaging (2020)

We identified several demographic, clinical, and neurobiological factors that are important to explain the variance in tau PET retention observed across the AD pathological continuum, non-AD neurodegenerative disorders, and cognitively unimpaired persons.

Keyphrases

computed tomography
positron emission tomography
cerebrospinal fluid
high resolution
cognitive decline
pet imaging
mild cognitive impairment
genome wide
copy number
mass spectrometry