Cascade Testing for Hereditary Cancer Syndromes: Should We Move Toward Direct Relative Contact? A Systematic Review and Meta-Analysis.
Melissa K FreyMuhammad Danyal AhsanHannah BergeronJenny LinXuan LiRana K FowlkesPriyanka NarayanRoni NiteckiJose Alejandro Rauh-HainHaley A MossBecky Baltich NelsonCharlene ThomasPaul J ChristosJada G HamiltonEloise Chapman-DavisEvelyn CantilloKevin HolcombAllison W KurianSteven M LipkinKenneth OffitRavi N SharafPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
Most relatives at risk for hereditary cancer do not undergo cascade genetic counseling and testing, forgoing potentially life-saving medical interventions. Compared with patient-mediated contact, direct relative contact increased rates of cascade genetic counseling and testing, arguing for a shift in the care delivery paradigm, to be confirmed by randomized controlled trials.