Novel concepts in atrial fibrillation ablation-breaking the trade-off between efficacy and safety.

Despite substantial technological and procedural advances that have improved the efficacy and safety of AF ablation in recent years, the long-term durability of ablation lesions is still not satisfactory. There also remains concern regarding rare but potentially life-threatening procedure-related complications like cardiac tamponade and atrioesophageal fistulae. Current ablation strategies are aiming to optimize the trade-off between efficacy and safety, where more extensive ablation appears to inevitably increase the risk of collateral injury. However, new forms of energy application may have the potential to resolve this quandary. The emerging concept of high power-short duration radiofrequency ablation features a more favorable lesion geometry that appears ideally suited to create contiguous lesions in the thin-walled atrium. Moreover, novel non-thermal ablation methods based on electroporation appear to provide a unique selectivity for cardiomyocytes and to spare surrounding tissues composed of other cell types. Both, high power-short duration and electroporation ablation might have the potential to break the trade-off between effective lesions and collateral damage and to substantially improve risk-benefit ratios in AF ablation. In addition, both approaches lead to considerable reductions in ablation times. However, their putative benefits regarding efficacy, efficiency, and safety remain to be proven in randomized controlled trials.