Acquired copy number amplification at the MYC enhancer in human B-precursor acute lymphoblastic leukemia cell lines.
Atsushi WatanabeLu WangTze King TanKevin Y UrayamaToshihiko KizukiChiaki KomatsuKeiko KagamiTamao ShinoharaShin KasaiMinori TamaiDaisuke HaramaKoshi AkahaneKumiko GoiHiroaki GotoKazuhito SatouTadashi KanameTakaomi SandaTakeshi InukaiPublished in: Cancer science (2024)
Our study highlights the discovery of recurrent copy number alterations in noncoding regions, specifically blood enhancer cluster (BENC-CNA), in B-precursor acute lymphoblastic leukemia (BCP-ALL) cell lines. We demonstrate that BENC-CNA acts as a super-enhancer, driving MYC expression and possibly contributing to the immortalization and proliferative advantage of BCP-ALL cells in vitro.
Keyphrases
- copy number
- acute lymphoblastic leukemia
- transcription factor
- mitochondrial dna
- binding protein
- genome wide
- allogeneic hematopoietic stem cell transplantation
- induced apoptosis
- endothelial cells
- dna methylation
- poor prognosis
- cell cycle arrest
- small molecule
- high throughput
- endoplasmic reticulum stress
- cell death
- cell proliferation
- acute myeloid leukemia
- label free