Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis.
Sybille KoehlerAlexander KuczkowskiLucas KuehneChristian JüngstMartin HöhneFlorian GrahammerSean EddyMatthias KretzlerBodo B BeckJörg HöhfeldBernhard SchermerThomas BenzingPaul T BrinkkoetterMarkus M RinschenPublished in: Journal of the American Society of Nephrology : JASN (2020)
We identified conserved mechanisms of the podocyte stress response through ultrasensitive proteome analysis of human glomerular FSGS tissue and purified native mouse podocytes during early disease stages. This approach enables systematic comparisons of large-scale proteomics data and phenotype-to-protein correlation.
Keyphrases
- high glucose
- endothelial cells
- diabetic nephropathy
- label free
- gold nanoparticles
- mass spectrometry
- electronic health record
- transcription factor
- big data
- quantum dots
- induced pluripotent stem cells
- protein protein
- pluripotent stem cells
- molecularly imprinted
- high resolution
- machine learning
- artificial intelligence