Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions.
Asha KarMarcus AlvarezKristina M GarskeHuiling HuangSeung Hyuk T LeeMilena DealSankha Subhra DasAmogha KokaZoeb JamalKaren L MohlkeMarkku LaaksoSini HeinonenKirsi H PietiläinenPäivi PajukantaPublished in: Genome medicine (2024)
Overall, we discover that obesity prematurely induces a decrease in ASPC proportions and identify 76 developmentally important ASPC genes that implicate altered negative regulation of fat cell differentiation as a mechanism for aging and directly link aging to obesity via significant cellular and genetic interactions.
Keyphrases
- insulin resistance
- genome wide
- adipose tissue
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- induced apoptosis
- fatty acid
- copy number
- skeletal muscle
- dna methylation
- bioinformatics analysis
- body mass index
- genome wide identification
- cell cycle arrest
- oxidative stress
- physical activity
- cell proliferation
- genome wide analysis