The Marine-Derived Triterpenoid Frondoside A Inhibits Thrombus Formation.

Emmanuel Ampofo Thomas SpäterLisa NalbachMichael D MengerMatthias W Laschke

Published in: Marine drugs (2020)

Our findings demonstrated that frondoside A inhibits agonist-induced CD62P expression and activation of GPIIb/IIIa. Moreover, frondoside A suppresses thrombus formation. Therefore, this marine-derived triterpenoid may serve as a lead compound for the development of novel antithrombotic drugs.

Keyphrases

poor prognosis
high glucose
signaling pathway
atrial fibrillation
drug induced
diabetic rats
endothelial cells