A standardized extract of Centella asiatica (ECa 233) prevents temporomandibular joint osteoarthritis by modulating the expression of local inflammatory mediators in mice.

Nattapon RotpenpianTawepong ArayapisitAtitaya RoumwongNarawut PakaprotMayuree TantisiraAree Wanasuntronwong

Published in: Journal of applied oral science : revista FOB (2021)

TRPV1, ASIC3, and CGRP expression increased in mice with TMJ-OA on day 21. All ECa 233 and ibuprofen doses inhibited pathogenesis by modulating the local expression of TRPV1 and ASIC3. Therefore, ECa 233 was more effective than ibuprofen.

Keyphrases

poor prognosis
oxidative stress
signaling pathway
binding protein
rheumatoid arthritis
high fat diet induced
long non coding rna
neuropathic pain
type diabetes
metabolic syndrome
spinal cord injury
spinal cord
mouse model
skeletal muscle
anti inflammatory