Resting-state functional-MRI in iNPH: can default mode and motor networks changes improve patient selection and outcome? Preliminary report.
Sara FabbroDaniele PiccoloMaria Caterina VescoviDaniele BagattoYan TereshkoEnrico BelgradoMarta MaieronMaria Cristina De ColleMiran SkrapFrancesco TunizPublished in: Fluids and barriers of the CNS (2023)
Our results suggest the presence of a partially reversible plasticity functional mechanism in DMN and MN. Low values compensate for the initial stages of the disease, while higher values of z-DMN were recorded in older patients with a longer duration of symptoms, suggesting an exhausted plasticity compensation. The standardization of this technique could play a role as a non-invasive biomarker in iNPH disease, suggesting the right time for surgery. Trial Registration Prot. IRB 090/2021.
Keyphrases
- resting state
- functional connectivity
- minimally invasive
- magnetic resonance imaging
- clinical trial
- study protocol
- coronary artery bypass
- phase iii
- randomized controlled trial
- magnetic resonance
- middle aged
- phase ii
- community dwelling
- depressive symptoms
- diffusion weighted imaging
- surgical site infection
- metal organic framework