Clinical, Histological, and Profibrotic Extracellular Matrix Protein Changes in a Model of Tracheal Stenosis Induced by Cervical Tracheal Autotransplantation.

Mariana Silva-Martínez J Raúl Olmos-Zuñiga Jazmin Calyeca Matilde Baltazares-Lipp Miguel Gaxiola-Gaxiola Andrea Nachón-Acosta Lya Edith Pensado-Piedra Fortunato Juárez-Hernández Roberto Sotelo-Robledo Rogelio Jasso-Victoria Antonia Luna-Flores Juan Carlos Vázquez-Minero

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2022)

Atx-Bleo in TS model rats produces tomographic and histological changes, and induces the upregulation of profibrotic proteins (TGFβ1, TGFβ2, collagen, FN, ELN, ITGβ1) and downregulation of antifibrotic proteins (TGFβ3, MMP1). Therefore, this model may be used to test new pharmacological treatments for reversing or preventing TS, and conduct basic studies regarding its pathophysiology.

Keyphrases

extracellular matrix
transforming growth factor
cell proliferation
signaling pathway
poor prognosis
epithelial mesenchymal transition
binding protein
case control
cone beam