Antimicrobial Activity of Gemini Surfactants with Azapolymethylene Spacer.
Iwona KowalczykMarta PakietAdrianna SzulcAnna KozirógPublished in: Molecules (Basel, Switzerland) (2020)
A series of 21 azapolymethylene gemini surfactants were obtained. The synthesis of the title surfactants in one- or two-step reaction proceeds with good yields. The structure and the purity of the synthesized compounds were determined by 1H and 13C NMR, ESI-MS spectra, and elemental analysis. Moreover, 2D COSY, HMBC, and HSQC spectra were performed. The minimal inhibitory concentrations (MIC) of the synthesized compounds were determined against fungi: Candida albicans, Aspergillus niger, Penicillium chrysogenum and bacteria: Escherichia coli,Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. Also, the critical micelle concentrations (CMC) were determined. The relationship between antimicrobial and surface activity and surfactant structure has been determined.
Keyphrases
- biofilm formation
- candida albicans
- staphylococcus aureus
- pseudomonas aeruginosa
- escherichia coli
- bacillus subtilis
- ms ms
- cystic fibrosis
- magnetic resonance
- mass spectrometry
- high resolution
- multiple sclerosis
- methicillin resistant staphylococcus aureus
- acinetobacter baumannii
- klebsiella pneumoniae
- solid state
- molecular dynamics
- cell wall