Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production.
Yun DengJian ZhaoDaisuke SakuraiAndrea L SestakVadim OsadchiyCarl D LangefeldKenneth M KaufmanJennifer A KellyJudith A JamesMichelle A PetriSang-Cheol BaeMarta E Alarcón-RiquelmeGraciela S AlarcónJuan-Manuel AnayaLindsey A CriswellBarry I FreedmanDiane L KamenGary S GilkesonChaim O JacobJoan T MerrillPatrick M GaffneyKathy Moser SivilsTimothy B NiewoldRosalind Ramsey-GoldmanJohn D ReveilleR Hal ScofieldAnne M StevensSusan A BoackleLuis M ViláI I Woong SohnSeung LeeDeh-Ming ChangYeong Wook SongTimothy J VyseJohn B HarleyElizabeth E BrownJeffrey C EdbergRobert P KimberlyRita M CantorBevra H HahnJennifer M GrossmanBetty P TsaoPublished in: Annals of the rheumatic diseases (2016)
We confirmed NMNAT2 and identified independent SMG7 association with SLE. The inverse relationship between levels of the risk allele-associated SMG7 mRNAs and ANA suggested the novel contribution of mRNA surveillance pathway to SLE pathogenesis.