Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas.
Yao YuJavier Villanueva-MeyerMatthew R GrimmerStephanie HilzDavid A SolomonSerah ChoiMichael WahlTali MazorChibo HongAnny ShaiJoanna J PhillipsBruce H WainerMichael W McDermottDaphne Haas-KoganJennie W TaylorNicholas ButowskiJennifer L ClarkeMitchell S BergerAnnette M MolinaroSusan M ChangJoseph F CostelloNancy Ann Oberheim BushPublished in: Neuro-oncology (2021)
TMZ-induced hypermutation is a common event in transformed LGG previously treated with TMZ and is associated with worse prognosis and development of discontiguous disease after recurrence. These findings impact tumor classification at recurrence, prognostication, and clinical trial design.