Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer.
Hanna Grauers WiktorinEbru AydinRoberta KiffinCaroline VilhavJohan Bourghardt FagmanMustafa KayaSanchari PaulBeatrice WestmanSvein Olav BratliePeter NarediKristoffer HellstrandAnna MartnerPublished in: Cancer research communications (2024)
Pancreatic cancer surgery triggered pronounced accumulation of NOX2+ myeloid-derived suppressor cells that inhibited NK cell function and negatively prognosticated postoperative patient survival. We propose the targeting of M-MDSC as a conceivable strategy to reduce postoperative immunosuppression in pancreatic cancer.
Keyphrases
- induced apoptosis
- patients undergoing
- minimally invasive
- cell cycle arrest
- coronary artery bypass
- reactive oxygen species
- cell death
- endothelial cells
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- case report
- free survival
- surgical site infection
- drug delivery
- diabetic rats
- drug induced
- induced pluripotent stem cells
- pluripotent stem cells
- atrial fibrillation