Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer.

Sophie Mouillet-RichardAngélique GougeletBruno PassetCamille BrochardDelphine Le CorreCaterina Luana PitasiCamille JoubelMarine SroussiClaire GalloisJulien LavergneJohan CastilleMarthe VilotteNathalie Daniel-CarlierCamilla PilatiAurélien de ReynièsFatima DjouadiSabine ColnotThierry AndréJulien TaiebJean-Luc VilotteBéatrice RomagnoloPierre Laurent-Puig

Published in: Journal of translational medicine (2024)

-dependent vicious circle is pathognomonic of poor prognosis, mesenchymal CRC. Patients from this aggressive subtype of CRC may benefit from therapies targeting the PRNP-CTNNB1-NR3C1 axis.

Keyphrases

poor prognosis
long non coding rna
stem cells
end stage renal disease
bone marrow
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
cell proliferation
protein protein
cancer therapy
patient reported outcomes
binding protein