Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults.
Georgia ColleluoriNicola NapoliUma PhadnisReina Armamento-VillarealDennis T VillarealPublished in: Oxidative medicine and cellular longevity (2017)
Diet, but not exercise or both, increases UcOC, whereas both diet and diet-exercise increase DI. UcOC accounts for DI variation only during active weight loss, while adipocytokines and physical function contribute to diet-exercise-induced DI variation, highlighting different mechanisms for lifestyle-induced improvements in insulin secretion. This trial was registered with ClinicalTrials.gov number NCT00146107.
Keyphrases
- weight loss
- physical activity
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- high intensity
- biofilm formation
- glycemic control
- resistance training
- weight gain
- obese patients
- body mass index
- adipose tissue
- cardiovascular disease
- escherichia coli
- oxidative stress
- high glucose
- randomized controlled trial
- body composition
- phase iii
- endothelial cells