Meta-Analysis of the Relationship between the APOE Gene and the Onset of Parkinson's Disease Dementia.

Suisui PangJia LiYingyu ZhangJiajun Chen

Published in: Parkinson's disease (2018)

Among the APOE genotypes, ε2+ is neither a risk factor nor a protective factor for PDD, while ε4+ is a risk factor for PDD. The present results are applicable to Asian, European, and American patients with Parkinson's disease. Regarding the single APOE genotypes, ε3/4 and ε4/4 may be risk factors for PDD; however, further studies with large sample sizes are needed to verify this.

Keyphrases

cognitive decline
systematic review
high fat diet
mild cognitive impairment
case control
risk factors
genome wide
randomized controlled trial
cognitive impairment
type diabetes
gene expression
copy number
adipose tissue
dna methylation
transcription factor
genome wide identification