Association and Effectiveness of PAX1 Methylation and HPV Viral Load for the Detection of Cervical High-Grade Squamous Intraepithelial Lesion.

Mingzhu LiChao ZhaoYun ZhaoJingran LiXiaobo ZhangWei ZhangQingqing GaoLihui Wei

Published in: Pathogens (Basel, Switzerland) (2022)

had the highest specificity in diagnosing CIN2+, followed by HPV16/18 VL, which are higher than cytology ≥ASCUS. (4) Conclusions: Hypermethylation of PAX1 is associated with high HPV VL, especially HPV16/18, and both present advantageous specificity in detecting CIN2+.

Keyphrases

high grade
low grade
randomized controlled trial
dna methylation
gene expression
structural basis
loop mediated isothermal amplification
label free
real time pcr
quantum dots
sensitive detection