The Pannexin 1/Purinergic Receptor P2X4 Pathway Controls the Secretion of MicroRNA-Containing Exosomes by HCV-Infected Hepatocytes.

Ok-Kyung KimDa-Eun NamYoung S Hahn

Published in: Hepatology (Baltimore, Md.) (2021)

These results suggested that HCV infection caused secretions of exosomes and exosomal miRNAs dependent on the caspase 3/Panx1/P2X4 pathway. Our study provides a possible therapeutic intervention using Panx1 suppression for liver disease development mediated by exosomes from HCV-infected hepatocytes.

Keyphrases

hepatitis c virus
mesenchymal stem cells
stem cells
human immunodeficiency virus
randomized controlled trial
cell death
liver injury
bone marrow
binding protein
hiv infected
antiretroviral therapy
endoplasmic reticulum stress