The Pro12Ala polymorphism of PPARγ2 modulates beta cell function and failure to oral glucose-lowering drugs in patients with type 2 diabetes.

Maria MasulliGiuseppe Della PepaSara CocozzaMario CapassoPiero PignataroMarilena VitaleAmalia GastaldelliMarco RussoPasquale DolceGabriele RiccardiAngela A RivelleseOlga Vaccaro

Published in: Diabetes/metabolism research and reviews (2020)

The Pro12Ala polymorphism is associated with a greater insulin sensitivity, reduced beta cell function and a substantially increased risk of treatment failure.

Keyphrases

anti inflammatory
insulin resistance
metabolic syndrome
combination therapy
fatty acid
skeletal muscle