Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer.
Reniqua HouseMrinmoyee MajumderHarinarayan JanakiramanBesim OgretmenMasanari KatoEvren ErkulElizabeth HillCarl AtkinsonJeremy BarthTerrence A DayViswanathan PalanisamyPublished in: PloS one (2018)
Our results indicate that miR-133a-3p is a target of smoking-induced changes in HPV(+) patients and alters the expression of EGFR and HuR which may promote HPV associated oropharyngeal cancer. Therefore, future treatment strategies for HPV(+) OPSCC smokers should focus on EGFR inhibition and the development of selective therapies to target HuR.
Keyphrases
- small cell lung cancer
- binding protein
- high grade
- epidermal growth factor receptor
- papillary thyroid
- poor prognosis
- tyrosine kinase
- smoking cessation
- end stage renal disease
- cervical cancer screening
- squamous cell
- chronic kidney disease
- prognostic factors
- lymph node metastasis
- long non coding rna
- childhood cancer
- diabetic rats
- oxidative stress
- young adults