Common Denominator of MASLD and Some Non-Communicable Diseases.
Katarzyna FerencSara Jarmakiewicz-CzajaAneta Sokal-DembowskaKatarzyna StasikRafał FilipPublished in: Current issues in molecular biology (2024)
Currently, steatohepatitis has been designated as metabolic dysfunction-associated steatohepatitis (MASLD). MASLD risk factors mainly include metabolic disorders but can also include genetic, epigenetic, and environmental factors. Disease entities such as obesity, diabetes, cardiovascular disease, and MASLD share similar pathomechanisms and risk factors. Moreover, a bidirectional relationship is observed between the occurrence of certain chronic diseases and MASLD. These conditions represent a global public health problem that is responsible for poor quality of life and high mortality. It seems that paying holistic attention to these problems will not only help increase the chances of reducing the incidence of these diseases but also assist in the prevention, treatment, and support of patients.
Keyphrases
- risk factors
- cardiovascular disease
- public health
- type diabetes
- end stage renal disease
- newly diagnosed
- ejection fraction
- metabolic syndrome
- dna methylation
- cardiovascular events
- gene expression
- chronic kidney disease
- risk assessment
- working memory
- weight loss
- genome wide
- oxidative stress
- skeletal muscle
- patient reported outcomes
- glycemic control
- body mass index
- cardiovascular risk factors
- replacement therapy
- patient reported
- global health