Phosphatidylinositol 4-Kinase III Alpha Governs Cytoskeletal Organization for Invasiveness of Liver Cancer Cells.
Cong Si TranJulia KerstenJingyi YanMarco BreinigThorben HuthTanja PothOmbretta ColasantiTobias RiedlSuzanne Faure-DupuyStefan DiehlLieven VerhoyeTeng-Feng LiMarit LingemannPhilipp SchultGustaf AhlénLars FrelinFlorian KühnelFlorian W R VondranKai BreuhahnPhilip MeulemanMathias HeikenwälderPeter SchirmacherRalf BartenschlagerVibor LaketaStephanie RoesslerDarjus Felix TschaharganehMatti SällbergVolker LohmannPublished in: Gastroenterology (2024)
PI4KIIIα regulates cytoskeleton organization via PIK3C2γ/Akt2/paxillin-cofilin to favor migration and invasion of liver cancer cells. These findings provide mechanistic insight into the contribution of PI4KIIIα and HCV to the progression of liver cancer and identify promising targets for therapeutic intervention.