The Impact of microRNA SNPS on Breast Cancer: Potential Biomarkers for Disease Detection.
Sakshi ChauhanRunjhun MathurAbhimanyu Kumar JhaPublished in: Molecular biotechnology (2024)
Breast cancer is considered a significant health concern worldwide, with genetic predisposition playing a critical role in its etiology. Single nucleotide polymorphisms (SNPs), particularly those within the 3' untranslated regions (3'UTRs) of target genes, are emerging as key factors in breast cancer susceptibility. Specifically, miRNAs have been recognized as possible novel approach for biomarkers discovery for both prognosis and diagnosis due to their direct association with cancer progression. Regional disparities in breast cancer incidence underscore the need for precise interventions, considering socio-cultural and economic factors. This review explores into the differential effects of SNP-miRNA interactions on breast cancer risk, emphasizing both risk-enhancing and protective associations across diverse populations. Furthermore, it explores the clinical implications of these findings, highlighting the potential of personalized approaches in breast cancer management. Additionally, it reviews the evolving therapeutic prospect of microRNAs (miRNAs), extending beyond cancer therapeutics to encompass various diseases, indicative of their versatility as therapeutic agents.
Keyphrases
- breast cancer risk
- genome wide
- papillary thyroid
- healthcare
- public health
- squamous cell carcinoma
- small molecule
- childhood cancer
- dna methylation
- randomized controlled trial
- risk factors
- young adults
- high throughput
- squamous cell
- risk assessment
- human health
- social media
- current status
- health information
- bioinformatics analysis
- single cell
- health promotion